Interferon-gamma or IFN γ or is a human dimerized soluble protein encoded by the IFNG gene. The biologically active IFN γ is an interlocking anti-parallel form of two monomers. IFN γ is the sole member of the type II IFN group. IFN γ binds to the IFN-γ receptor complex to elicit a cellular signal. Two subunits, IFNGR1 and IFNGR2, make up the IFN-γ receptor complex. IFN γ plays a crucial role in innate and adaptive immunity. It inhibits viral replication, fights against bacteria, and modulates and stimulates the immune system.
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Interferon-gamma is a human protein produced in cells of the immune system. More specifically, it is encoded for by the IFNG gene in humans, and the IFNGR2 gene in other mammals. It acts as an immunomodulatory protein during the immune response, where it binds to two receptors: IFNGR1, which is a transmembrane receptor expressed on B and T cells, and IFNGR2, which is expressed on natural killer cells. Interferon-gamma plays a crucial role in innate and adaptive immunity. It inhibits viral replication, fights against bacteria, and modulates and stimulates the immune system.
Interferon gamma elisa is a dimeric soluble protein encoded by the IFNG gene in humans. It plays a crucial role in the immune system’s innate and adaptive immunity. Efficient processing of interferon gamma includes transport across the cell membrane and glycosylation, proteolytic maturation, and subsequent binding to two subunits of IFN-γ receptor complex.
IFN γ, also known as IFN gamma, is the second type of interferon. Known as immune interferon, it prevents viral replication by binding to and inhibiting various viruses such as Hepatitis B and HIV. Interferon gamma is used for autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, kidney transplant rejection, skin graft rejection and psoriasis.
Fighting infections is a very complex and busy process. In addition to the immune system, cells and biological molecules are involved to protect your body against the harmful intruders such as viruses, bacteria and fungi. They work closely together to recognize and kill the intruders by using specific receptors on cell surfaces, antibodies and certain protein molecules. Interferon gamma or IFN-γ plays an important role in both innate and adaptive immunity. It can activate natural killer cell activity and also help to induce antibody production.
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Cystatin C test is an important kidney biomarker. It is a basic non-glycosylated protein characterized by long and short alpha-helices. The CST3 gene encodes cystatin C, which belongs to the gene family of type 2 cystatin. Researchers mainly use cystatin C levels and study the cystatin C glomerular filtration rate (GFR) to detect kidney disorders, but recent studies also explore cystatin C’s role in predicting cardiovascular diseases and association with amyloid plaques in neurological disorders.
Cystatin C is an important kidney biomarker. Researchers first described Cystatin C as a gamma trace found in the urine and cerebrospinal fluid of patients with kidney failure. All nucleated human cells produce cystatin C. CST3 gene encodes cystatin C, which belongs to the gene family of type 2 cystatin. The CST3 gene is present in the cystatin locus on chromosome 9.
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